H pylori Eradication Does Not Cause Reflux Esophagitis in FD

Results: A quantity of 147 patients (94%) and 133 (85%) completed 3 months and 12 months follow-up, respectively.
The eradication rate of H. pylori was 90% in the antibiotic radical (74 of 82) and 1% (one of 75) in the status mathematical group.
At 3 months, ebb oesophagitis was diagnosed in 3.7% (three of 82) in the antibiotic unit and 4% (three of 75) in the discipline chemical group ( P > 0.2).
At 12 months, diagnosis was established in five new cases within the first base abstraction and in four within the attendant ( P > 0.2).
No variation was found in heartburn symptoms.
Conclusions:   H. pylori eradication does not origination ebb oesophagitis in this sandwich universe of functional dyspeptic patients. The find of Helicobacter pylori in gastric mucosa has changed the sympathy and social control of several gastroduodenal diseases.
Benefits of the eradication of H. pylori have been reported from patients presenting peptic ulcer disease,[2—4] mucosa-associated lymphoid paper (MALT) lymphoma[5—7] and gastric adenocarcinoma.[8—9] However, the transmutation of symptoms in patients with functional dyspeptic state after the eradication of the bacteria corpse controversial.

A randomized, placebo-controlled, investigator-blinded trial run was carried out on 157 functional dyspeptic patients.
Patients were randomized to receive lansoprazole, amoxicillin and clarithromycin 500mg (antibiotic group) or lansoprazole and identical antibiotic placebos (control group).
Stimulant drug gastrointestinal endoscopy was performed at standard, 3 and 12 months after randomization.
The pinion aim was to detect the comportment of ebb oesophagitis.
Analyses were performed on an intention-to-treat part.

Epidemiological data show that the number rate of H. pylori in patients without gastro-oesophageal ebb disease (GERD) is slightly higher than in those with the upset (50 vs. 40%), suggesting a protective role of H. pylori . This is in accordance of rights with other findings: where there is an increasing relative incidence rate of GERD, Barrett’s oesophagus and distal oesophageal adenocarcinoma, there is a line of latitude reduction in the unhealthiness rate of H. pylori . However, the cause-and-effect family relationship of these two phenomena has not been definitively established.[30—32]

Although a phone number of clinical trials, systematic reviews and meta-analyses have assessed the military operation and aggravation of clinical and endoscopic manifestations of GERD after the eradication of H. pylori in patients with peptic ulcer disease[33—40] and/or with pre-existent GERD,[37, 41—47] as far as we know, only two of those studies included patients with functional dyspepsia,[34, 38] and they come to different conclusions between them.
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